Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy
نویسندگان
چکیده
منابع مشابه
Effects of sildenafil on the viability of random skin flaps.
PURPOSE To assess the viability of McFarlane skin flaps in rats with administration of sildenafil. METHODS Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they ...
متن کاملCapsaicin on the viability of random-pattern skin flaps in rats.
PURPOSE To evaluate the effects of capsaicin on the viability of ischemic random-pattern skin flaps in rats. METHODS Forty EPM1-Wistar rats were randomized into two groups of 20 animals each, the capsaicin group and the control group. A random-pattern skin flap measuring 10 x 4 cm was raised and a plastic barrier was placed between the flap and the donor site. After the surgical procedure, th...
متن کاملImproved viability of random pattern skin flaps with the use of bone marrow mesenchymal-derived stem cells and chicken embryo extract
Objective(s): Covering tissue defects using skin flaps is a basic surgical strategy for plastic and reconstructive surgery. The aim of this study was to evaluate the effects of chicken embryo extract (CEE) and bone marrow derived mesenchymal stem cells (BM-MSCs) on random skin flap survival (RSF) in rats. Using chicken embryo extract can be an ideal environment for the growth and proliferation ...
متن کاملIsoflurane preconditioning increases survival of rat skin random-pattern flaps by induction of HIF-1α expression.
BACKGROUND Survival of random-pattern skin flaps is important for the success of plastic and reconstructive surgeries. This study investigates isoflurane-induced protection against ischemia of skin flap and the underlying molecular mechanism in this process. METHODS Human umbilical vein endothelial cells (HUVECs) and human skin fibroblast cells were exposed to isoflurane for 4 h. Expression o...
متن کاملEffects of Clopidogrel and Low-Molecular-Weight Heparin on Viability of Random Skin Flaps in Rats
The transfer of tissue via skin flap, which generally remains connected (via pedicle) to the donor area, is widely used in all areas of reconstructive surgery to close cutaneous defects.1–3 However, flap necrosis is still a threat, with serious consequences for the patient. Several publications are nowdevoted to techniques for enhancing flap viability. Flap necrosis may be intrinsic or extrinsi...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2019
ISSN: 1663-9812
DOI: 10.3389/fphar.2019.01017